Paralympians will be expected to win at least 103 medals from 12 sports at London 2012, with the goal of finishing second in the medals table.
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UK Sport want ParalympicsGB to secure runner-up position for the third successive Games later this summer.
Not intimidated by their counterparts' success at the Olympics, ParalympicsGB are convinced they can "go one better".
Baroness Sue Campbell CBE, Chair of UK Sport, said: "British Paralympic sport is better-resourced, and in a stronger position than ever before."
Based on data from all 18 funded Paralympic sports, UK Sport sets its sight on a maximum of 145 medals from 16 sports.
Britain's Paralympic campaign towards London 2012 started in 2009 and has been backed by over £49 million of funding.
The prime minister announced last week that funding for elite sport would continue into the preparations cycle for the next Olympic Games in Rio de Janeiro in 2016.
Secretary of State for Culture, Olympics, Media and Sport, Jeremy Hunt, said: "After a fantastic Olympics all eyes will be on our Paralympic athletes. Every member of ParalympicsGB will be going all-out to deliver their best ever result, and I wish the team the very best of luck."