Sam and Kovac set off in search of her diabetic son Alex, who has run away in search of his father but forgotten to take his insulin. Neela, Ray and Abby are on their first shift in charge of interns.
Ray attends to Claire, a surrogate mother who goes into premature labour after being involved in a car accident. Pratt deals with his feelings after encountering his estranged father.
The emergency room is jolted when a new nurse manager, Eve Spellman, enforces her strict and efficient new procedures. Meanwhile, Kovac and Sam do not enjoy working the same shift.
A patient who has been in a coma for nine years suddenly awakens in the emergency room. Abby comforts Dr Dubenko after he hears disturbing news.
Pratt gets a surprise when the new attending doctor poses as a patient to test the knowledge of doctors in the emergency room. And a breast cancer patient convinces Abby to get a mammogram.
Clemente, Abby and Neela secretly care for a very important patient while Dubenko tortures the ER staff via a robotic television camera from his home
Neela prepares for Gallant's homecoming from the war, but her plans change when she receives a call from Iraq. Abby is caught in the crossfire of a disagreement between Kovac and Clemente.
When two commuter planes crash in midair and land on a densely populated area of Chicago, Neela and Gates rush to help the victims. Pedestrians as well as passengers are injured.
After returning from Iraq, Gallant surprises Neela by telling her he wants to take their relationship to the next level. Meanwhile, Morris shocks everyone by standing up to Weaver.
After a little girl is mistakenly shot, Pratt and Weaver desperately try to revive her. Haleh holds her annual choir tryouts and the choice for the solo is a surprise.
Neela and Kovac help a pregnant teenager, Ray gets a once-in-a-lifetime opportunity with his band, and Clemente's past catches up with him when the police enter the emergency room
Clemente is missing, and Dr Dubenko volunteers to take the dayshift but ends up feeling overwhelmed. Ray's ex-girlfriend enters the emergency room with serious abuse-related injuries.
When a patient with Lou Gehrig's Disease arrives at the emergency room, many of the doctors are shocked to recognise him as former medical school professor Dr Nate Lennox
An unexpected visitor puts Clemente in the middle of a domestic dispute, while Pratt finds himself the centre of unexpected attention at a gala, and Abby and Kovac have an anxious wait
Carter is joined by Dr Dakarai in the Sudanese desert as they treat hundreds of disease-infested and famine-stricken people. Back at County General, Clemente returns from New Jersey with open wounds.
Weaver contemplates hip replacement surgery and, after attending to a wealthy fainting victim, Sam receives an intriguing job offer, and Neela decides to attend a support group for military spouses
Abby and Kovac fight to keep a young woman with stab wounds alive long enough for a surgeon to operate. When her condition worsens Clemente steps in, performing a risky procedure
When the police bring in two teenagers involved in a car accident, Abby and Morris struggle to figure out what exactly is wrong with the unconscious girl. And Neela gets a visit from her in-laws.
Abby senses something is not what it seems when she treats a child and her grandmother, then disagrees with Luka over the best course of action. Pratt heads to Africa to help Carter.
Carter, Pratt and Dakarai find themselves in the middle of the conflict in Darfur when a man and his pregnant wife arrive at the camp. Carter and Dakarai try to operate on the man's gunshot wound.
On his return from Darfur, Pratt struggles to get the real story from two abused boys and their injured father. Clemente's behaviour grows more and more erratic, forcing Kovac to take a stand.
In the aftermath of tragedy, the ER starts returning to normality. But it's not long before the calm is shattered by the arrival of two prisoners.