Frey underwent tests this week for a knee problem and, although the injury is not considered serious, the pain is enough to rule him out of Saturday’s Serie A match.

He is not even in the squad travelling to San Siro, but neither is second choice shot-stopper Vlada Avramov after coming down with a bout of flu.

This means veteran Marco Storari will be in goal and youth team goalkeeper Andrea Seculin on the bench.

Adrian Mutu, Sergio Almiron, Da Costa, Ndiaye Papa Waigo and Martin Jorgensen are also sidelined, but Riccardo Montolivo returns from a one-match ban.

New signing Emiliano Bonazzoli – who arrived from Sampdoria this week in part-exchange for Giampaolo Pazzini – makes his debut in the Viola jersey.

Fiorentina squad: Bonazzoli, Comotto, Dainelli, Donadel, Gamberini, Gilardino, Gobbi, Jovetic, Kroldrup, Kuzmanovic, Melo, Montolivo, Pasqual, Santana, Seculin, Semioli, Storari, Vargas, Zauri.