American tourist Frank Tupelo (Johnny Depp) is visiting Italy to mend a broken heart. On a train to Venice, the beautiful Elise Clifton-Ward (Angelina Jolie) sits next to him, and a romance seems to bud. Elise invites Frank to stay with her at a hotel, and then to attend a ball in the evening.
But there's more to this seemingly flawless girl than meets the eye: hers is a complex world of vicious gangsters, fraud and millions of stolen dollars.
And Elise has placed him at the centre of it merely as a decoy, hoping to convince her pursuers that he is her real lover, his appearance altered by plastic surgery, so that she and her embezzler boyfriend can make good their escape.
It seems to work: when Elise abandons him at the ball, Frank is chased by gangster Reginald Shaw (Steven Berkoff) and his men. But soon Frank and Elise are thrown back together, tangled in a mess of boat chases and gunshots, as they attempt to avoid both the police and the gangsters.
Also starring Paul Bettany, Timothy Dalton and Rufus Sewell.
(2010) Cert: 12