Ugly Betty

Smash-hit US comedy drama. In the superficial world of high fashion, image is everything. How can an ordinary girl - a slightly plump plain Jane from Queens - possibly fit in? [S] More on Ugly Betty

Last broadcast: 27 December 2010, on

90210

Prepare to revisit the hottest postcode in the USA. The kids from West Beverly High might be rich and privileged, but they've always got some drama going on... [S] More on 90210

Next on: Tuesday 21 February, 9PM on E4

Rules of Engagement

US sitcom about modern relationships as seen through the eyes of two couples and a single guy [S] More on Rules of Engagement

Next on: Thursday 16 February, 8.30PM on E4

My Name Is Earl

Smash-hit US comedy. Petty crook Earl decides he's got bad karma, and tries to turn his life around by righting all the wrongs from his past. But it's a long list - and things don't always pan out as planned... [S] More on My Name Is Earl

The Big Bang Theory

Arch-nerds Leonard and Sheldon may know more than their fair share about subatomic particles, but when it comes to people in general, and women in particular, they're absolutely clueless... [S] More on The Big Bang Theory

Last broadcast: Thursday 05 January, 8PM on E4

New Girl

US comedy about a woman who moves in with three single guys after breaking up with her boyfriend [S] More on New Girl

Next on: Friday 17 February, 8.30PM on Channel 4

Supernanny US

Jo Frost takes her unique style of parenting to the mums and dads of the United States [S] More on Supernanny US

Next on: Friday 17 February, 8PM on E4

The Simpsons

Homer. Marge. Bart. Lisa. Maggie. They're unique, they're extraordinary, and they're yellow. Say hello to the Simpsons. More on The Simpsons

Last broadcast: Sunday 01 January, 12.40AM on Channel 4

Desperate Housewives

Dark comedy drama exploring the complicated reality behind the apparent domestic bliss of a group of housewives in a fictitious American suburb [S] More on Desperate Housewives

Next on: Tuesday 21 February, 11.10PM on Channel 4

Frasier

A successful radio talk show host and sophisticated man-about-town, all life's dice seem loaded in favour of Dr Frasier Crane. Intelligent, affluent, unattached - what could go wrong? Quite a lot, actually... More on Frasier

The Good Wife

Drama starring ER actress Julianna Margulies as Alicia Florrick, a politician's wife who has to transform herself into a career woman when a political and sex scandal lands her husband in prison [S] More on The Good Wife

Next on: Thursday 16 February, 9PM on More4

Shameless USA

The US version of the hit comedy drama, with William H Macy as Frank Gallagher, working-class patriarch to a brood of six spirited and independent children [S] More on Shameless USA

Last broadcast: Thursday 08 September, 10PM on More4

Happy Endings

US comedy. Alex and Dave's wedding was going to be the happiest day of their lives; until Alex left Dave at the altar... [S] More on Happy Endings

Next on: Thursday 16 February, 9.30PM on E4

Smallville

Before the legend of Superman came a boy named Clark Kent. Someday, he'll master his powers and understand his true calling, but for now he just has to get through adolescence... [S] More on Smallville

Last broadcast: Tuesday 01 November, 9PM on E4

One Born Every Minute USA

American version of One Born Every Minute, the show that looks at the drama and emotion of a maternity unit from the perspective of the parents-to-be and the maternity ward staff [S] More on One Born Every Minute USA

Last broadcast: 04 August 2011, on

The Cleveland Show

Cleveland Brown, from Family Guy, waves goodbye to Peter Griffin and heads back to Virginia with his teenage son to rekindle his romance with high school sweetheart Donna in this animated comedy series [S] More on The Cleveland Show

Next on: Tuesday 21 February, 10PM on E4

The Daily Show with Jon Stewart

Emmy award-winning Jon Stewart takes a satirical, irreverent look at the news, trends, pop culture, sports and entertainment, featuring news footage mixed with on-the-spot coverage [S] More on The Daily Show with Jon Stewart

Next on: Monday 20 February, 11.10PM on More4

Homeland

Compelling US thriller starring Claire Danes and Damian Lewis. An American soldier left for dead in Iraq is rescued after years in captivity - but can the returning hero's story be trusted? More on Homeland

Next on: Sunday 19 February, 9.30PM on Channel 4

Franklin & Bash

In this American comedy drama, streetwise lawyers and life-long friends Jared Franklin and Peter Bash are recruited to shake things up at a stuffy law firm [S] More on Franklin & Bash

Last broadcast: Wednesday 14 September, 10.20PM on E4

Privileged

Intriguing US drama. Megan Smith has a Yale education, a relentlessly positive attitude and a foolproof plan to conquer the world of journalism. But then she gets fired and her life turns upside down... [S] More on Privileged

Last broadcast: 15 November 2009, on

One Tree Hill

Love, life and basketball in Tree Hill, a small town in North Carolina that sees far more than its fair share of teen drama [S] More on One Tree Hill

Last broadcast: Monday 21 November, 9PM on E4

Allen Gregory

Allen Gregory De Longpre may be just seven years old, but he's travelled the world and considers himself intelligent, sophisticated, worldly, artistic and romantic. But now he faces his biggest challenge: elementary school. [S] More on Allen Gregory

Next on: Sunday 19 February, 1.10AM on E4

Perfect Couples

US comedy about three couples who are trying different ways to keep the spark in their relationships alive [S] More on Perfect Couples

Last broadcast: Thursday 08 December, 8.30PM on E4

St Elsewhere

A medical drama made by the Hill Street Blues team set in St Eligius, an understaffed and overburdened Boston teaching hospital, nicknamed St Elsewhere [S] More on St Elsewhere

American Football Live

American Football is back and every week there will be two top NFL teams going head to head - live on Channel 4 More on American Football Live

Last broadcast: Monday 26 December, 1.10AM on Channel 4

Southland

Gritty police drama set on the lawless streets of Los Angeles where rookie cop Ben, his hard-as-nails training officer John, multi-tasking detective Lydia and their team in the Los Angeles Police Department live and work [S] More on Southland

Last broadcast: Thursday 15 December, 9PM on More4

The Closer

Complex US crime drama. World-class interrogator Brenda Leigh Johnson, an expert at obtaining confessions, heads a special unit of the LAPD that handles sensitive, high-profile murder cases [S] More on The Closer

Last broadcast: Thursday 29 December, 10PM on More4

Dirty Sexy Money

Hit US drama. Idealistic attorney Nick George is persuaded to take on some less than ideal clients - the wealthy and immoral Darling family. This is one lawyer who will never be short of work... More on Dirty Sexy Money

The Killing

US drama which ties together three stories around a single murder, including the detectives assigned to the case, the victim's grieving family and the suspects. As the case unfolds, it becomes clear that everyone has a secret... [S] More on The Killing

Last broadcast: Thursday 15 September, 9PM on Channel 4

Gilmore Girls

The lives and loves of Lorelai and Rory Gilmore, a single mother and her daughter who are who are more like sisters More on Gilmore Girls

True Blood

Mature vampire drama from the creator of Six Feet Under, which follows a telepathic barmaid called Sookie who is bored by life until she meets Bill Compton - a mysterious 173-year-old vampire [S] More on True Blood

Last broadcast: Tuesday 29 November, 11.10PM on Channel 4

Without a Trace

Fast-paced, award-winning US drama. Each year, thousands of people go missing in New York. Have they been abducted or murdered, have they committed suicide - or are they on the run? [S] More on Without a Trace

Last broadcast: Tuesday 22 November, 4.40AM on Channel 4

Curb Your Enthusiasm

Critically acclaimed comedy series starring Larry David (co-creator and executive producer of Seinfeld) as... Larry David! More on Curb Your Enthusiasm

Last broadcast: Sunday 20 November, 11.10PM on More4

Hill Street Blues

Gritty and groundbreaking US ensemble drama that chronicles the lives of the overworked staff of an inner city American police precinct. Remember, let's be careful out there... [S] More on Hill Street Blues

5ive Days to Midnight

Two-part American thriller packed with twists, turns and a terrifying countdown to one man's death, starring Oscar-winner Timothy Hutton More on 5ive Days to Midnight

The Event

A high-octane US thriller starring Jason Ritter as a man whose investigation into the mysterious disappearance of his fiancée unwittingly exposes the biggest cover-up in American history... [S] More on The Event

Last broadcast: 30 May 2011, on

The OC

Orange County, California, is home to the beautiful people. But a tough teenager from the wrong side of the tracks soon discovers they are just as territorial, and ruthless, as the street gangs of his past... More on The OC

ER

Multi-award winning US drama created by prolific novelist Michael Crichton that follows the busy lives of the hard-pressed doctors, nurses and support staff of a hectic inner-city emergency room More on ER

Joan Rivers Comedy Roast

UK premiere of this comedy programme in which Joan Rivers faces Carl Reiner, Tom Arnold and Donald Trump as they take turns in teasing her about her life and also in celebrating it More on Joan Rivers Comedy Roast

William Shatner Comedy Roast

UK premiere of this comedy programme in which Star Trek actor William Shatner faces Jason Alexander, Fred Willard and George Takei and others as they take turns in ribbing him about his life More on William Shatner Comedy Roast

Pamela Anderson Comedy Roast

Jimmy Kimmel, Courtney Love, Sarah Silverman, Bea Arthur and Tommy Lee take turns in paying humorous tribute to Baywatch actress Pamela Anderson in this comedy roast More on Pamela Anderson Comedy Roast

Will and Grace

Hit US odd couple sitcom. She's a beautiful and charming interior decorator. If only she could find the right man. He's a likeable and successful Manhattan lawyer. If only he could find the right man... [S] More on Will and Grace

Roswell

US sci-fi drama. Human-alien hybrids Max, Isabel, Michael and Tess attempt to integrate into life among humans in the infamous New Mexico city of Roswell, only to find that this might not be so easy... More on Roswell

The Dead Zone

Horror drama series based on the Stephen King novel More on The Dead Zone

Last broadcast: 14 March 2010, on

Generation Kill

Generation Kill is a gritty dramatisation of Rolling Stone journalist Evan Wright's experience as an embedded reporter with the United States Marine Corps during the 2003 invasion of Iraq [S] More on Generation Kill

The West Wing

This acclaimed US political drama takes a behind-the-scenes look at the Oval Office through the eyes of an eclectic group of White House staff led by President Josiah Bartlet, brilliantly played by Martin Sheen More on The West Wing

John Adams

Multi-award winning US historical drama series that explores American history and offers an intimate portrait of one of its great founding fathers, John Adams More on John Adams

Ghost Whisperer

Spooky US drama. Melinda Gordon has a gift. She can communicate with dead people, who seek her help to resolve unfinished business. But sometimes Melinda's gift can feel like a curse... More on Ghost Whisperer

Back to You

Kelsey Grammer and Patricia Heaton are co-news anchors who meet again at a Pittsburgh television station after working together previously in the '90s. It's not always a happy reunion... More on Back to You