When a mission smuggling drugs from Bolivia to Chile is brutally ambushed, four men become fugitives from the cops and a rival cartel. Each is hiding something, but they must stay together to survive.
The fugitives find refuge with an old comrade-in-arms of Salamanca's. Vicente operates on Tegui. A survivor of the port ambush - the son of powerful drug trafficker Cacho Aguilera - is taken hostage.
The group follow the trail of Cacho Aguilera and try to exchange Salamanca's daughter Irma for Aguilera's son Ivan. But when one party fails to maintain their end of the deal, war breaks out.
After an assassination attempt, Ferragut cartel boss Kika is transferred from prison to hospital and Vicente tries to arrange a rescue mission. Salamanca suspects that Tegui is an undercover agent.
The fugitives - now joined by Kika, her daughter Laura, and Irma - try to obtain some cash to help them reach the border. Ximena tries to establish a connection between the drug traffickers and Oliva.
The web of deception engulfing the fugitives grows more complex as they wait to cross the border. The relationship between Oliva, Fabian and Ximena grows more tense, resulting in Fabian's dismissal.
Gabriela's killer is exposed and pays dearly for his actions. The fugitives - with Irma, Laura and Kika in tow - flee on foot to hide in a spiritual retreat house, where passions come to the surface.
After a bloody confrontation, the fugitives must split up for their own safety. As Salamanca's health deteriorates, he faces facts and confronts tragedies from his past. Tegui and Laura grow closer.
The Ferragut clan is betrayed again, and Aguilera tries to avenge the death of his son. Irma is intent on seeking her own revenge. Tegui asks Ximena for help, handing her evidence that could save him.
Aguilera and his men attack the area where the fugitives are hiding out, and the true identity of Moreno is revealed. Ximena places her trust in Minister Adriana Bascunan and shows her Tegui's video.
Salamanca and Moreno confront each other, but there is a drastic outcome. Vicente sets out in search of the codes to the Ferragut bank accounts. Once again, Ximena decides to trust Adriana Bascunan.
How long will Moreno last before his fellow fugitives catch up with him? The war between the cartels escalates. Determined to clear Tegui of all guilt, Ximena shares information about the conspiracy.
Vicente and Laura plan to escape by boat to Peru, but an unexpected betrayal changes things. Tegui gets ready to unmask the conspiracy, face justice and clear his name, but Bascunan has other plans.
Crime thriller following four men whose lives are turned upside down when a drug deal goes wrong. Fugitives is the first Chilean show to be broadcast in the UK.