The final film of the series sees the children reach the age of five.
Zoe has worked hard and progressed, but she and her mum, Anne Marie, now have to accept that her condition will mean she needs a wheelchair.
Nathan's Down's syndrome hasn't stopped him taking the huge step of starting at the local mainstream primary school. His parents Tracey and Richard have been amazed by his progress, as his speech improves every day and he makes friends.
Emily starts school still wearing nappies and faces further surgery, but seems unfazed.
William's is still having regular seizures. His parents turn to the controversial drug Ritalin to see if it can help improve his erratic behaviour and quality of life.
Shelbie has started at special school and enjoys PE.
Hamish is a very active child, but has started to ask his parents why he is shorter than his friends, while they discuss whether painful leg-lengthening surgery would help.
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