With diplomatic moves to end Syria's conflict locked in paralysis, there is a very real danger the country's huge chemical weapons stockpile could either be used or fall into the hands of jihadists.
In separate announcements, US Defense Secretary Chuck Hagel and the British Foreign Office state there is evidence that Damascus has used chemical weapons.
Video footage released by activists shows Syrian rebels fighting inside the Great Umayyad Mosque of Aleppo immediately after its famous minaret is destroyed.
A British mother is trapped alongside her children in Syria as her estranged husband won't give his permission for her to leave the country.
The UN envoy to Syria, Lakhdar Brahimi, tells Channel 4 News it is "desperately urgent" parties work together to end the war but admits he has not spoken directly to President Assad in three months.
Jihadists are increasingly prominent in the fight against the Syrian government, which has so far claimed over 70,000 lives. Channel 4 News maps the gains made by the most powerful groups.
The leader of the opposition Syrian National Coalition (SNC) Ahmed Moaz al-Khatib resigns, in a blow to a diminishing moderate wing of the two-year uprising against President Bashar al-Assad's rule.
Rebels seize a strategically significant Syrian air defence base, activists say, as fighting rages near Syria's border with Israel.
A decade since the war in Iraq, a YouGov poll reveals half the British people are against giving Syria's rebels any military hardware whatsoever.